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About Port 25 Block Issue
Each and every Internet application, such as web, mail or ftp is assigned a unique port number by the Internet Assigned Names Authority (IANA). When a computer running mail server software starts up, it attaches to that port and uses it to listen for incoming requests. Because the port numbers are standardised across the Internet, clients can make reasonable assumptions about which port is the proper destination for a given service. When your computer needs to deliver an email to another person for example, it connects to a server on port 25 and sends the email to it. This server then sends it on to its destination. Because of the standard, you can always assume that port 25 is the SMTP mail server, not the HTTP (web) server which is port 80, or some other service.
Why do Internet Service Providers block(ISP) port 25?
Many ISP's (Internet Service Providers) are blocking what is called "Port 25" which is the port used to send e-mail. For example, the Earthlink, one of the ISP that blocking the port 25. You may get more detail at http://help.earthlink.net/port25/.
These ISPs have chosen to do this to cut down on the amount of "SPAM" mail that is sent. All e-mail sent via the Internet is routed through the port 25, the channel used for communication between a mail client and a mail server. Even though port 25 blocking will probably become an industry standard, however, the filter can create problems for e-mail servers and block legitimate e-mail as well as spam. You can check with your dial-up provider to see if they are doing this.
Unfortunately, there is nothing we can do to change this. The port 25 is the standard for sending messages. You can change the incoming port in Mail Express, but the servers with which the program has to communicate to deliver the messages wait for connections on port 25.
One way around this is to set your SMTP settings to those of your ISP's. They can provide the settings for you to send email via their SMTP server. For example: "mail.aol.com". After doing that, you will be sending mail though your ISP's servers rather than the SMTP server on your computer. Unfortunately, you will not be able to use any SMTP mail server software, including the delivery engine of Mail Express Series.
How to send email bypass port 25 block issue?
There are Three ways to bypassing this problem:
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Use socks proxy server
In this way, you may set up a socks proxy server in Mail Express. Mail Express support socks4, socks4A and socks5 proxy server. These proxy servers don't use the port 25. To get more infomation about set up a socks proxy server, you may read the help file. This is not a good solution to solve the port 25 block issue, because the socks servers are not stable and fast enough.
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Use the ISP's SMTP server in Mail Express Series
In Mail Express Series softwares, you may add more other SMTP serverin the Delivery Engine List. When Mail Express can not send email with its own delivery engine, it will try to relay the email to the SMTP server you have set in it. It mean that you can also add your ISP's SMTP server in it. So in any case, you needn't to change the SMTP setting in your mail client, Mail Express can integrate your all SMTP servers, such as your ISP's and your company's, into one interface ( see here). This solution is not very well for many users who need to send many emails or newsletters to their customers or subscribers, the ISP alway limit the send-out email count in a certain time period.
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Use Across-Mail Service
 This is a complete solution for you to solve the port 25 block issue. AMS(Across-Mail Service) is a service to help users send email bypass the problems of your ISP, include port 25 blocking. AMS also support SSL security connection to protect your account information and email content. This service can work with your favorite mail client programs (such as Outlook Express, Netscape, Eudora, etc.) or email clients in other platforms (such as Mac, Unix, Linux, Pocket PC and other mobil machines), and our Mail Express Series, to get more information about how to send email through Across-Mail Series, please visite " How to use Across-Mail Service". Through AMS, you can send up to 6000 emails or more in a day and up to 150000 emails or more in a month. Click here to get more information about Across-Mail Service or click here to sign up an AMS account (you can sign up a Free Solution account to test AMS if it is helpful for you before purchase it).
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Use AMSGEM (AMS Global Electronic Marketing)
 If you need the Email Marketing Service with Tracing System support, please try our EDM service - AMSGEM (Global Electronic Marketing). Click here to know more about AMSGEM.
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Another thing you can do is to signup with another ISP. Smaller local ISP's usually do not block Port 25. Here are some web sites that can help you find thousands of ISPs:
Another issue for Mail Express Series users that their ISP blcok port 25
For some users, when the SMTP Port setting of Mail Express is set to port 25 and start Mail Express, they will find that the Receive Server can not be started (The first led in the bottom stat bar is red), click the "Start Receive Server" button also can not start the Receive Server, the reason is the port 25 block issue of their ISP, for example, users of pipex.com. To solve this problem, you must change the SMTP Port setting of Mail Express (this setting is in Options -> SMTP tab) from 25 to another value, such as 26, of course, you must make the same change in your mail client setting.
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